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Morphofunctional Characteristics of the Kidneys in Chronic Endotoxemia against the Background of Hyperthyroidism

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Bulletin of Experimental Biology and Medicine Aims and scope

Simulation of chronic endotoxemia in rats leads to the development of nephropathy and nephrosclerosis. Kidney involvement was more pronounced in animals with endotoxemia developing against the background of hyperthyroidism. Direct effects of bacterial LPS and its secondary effects mediated through circulating LPO products under conditions of thyroid hormone excess caused damage to the renal tissue. Immunohistochemical studies demonstrated higher expression of apoptosis markers in nephrocytes of the proximal tubules in rats with hyperthyroidism.

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Authors and Affiliations

  1. Volgograd State Medical University, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia

    S. A. Kalashnikova & G. A. Kovnatskaya

  2. V. I. Kulakov Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia

    A. I. Shchogolev

Authors
  1. S. A. Kalashnikova
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  2. G. A. Kovnatskaya
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  3. A. I. Shchogolev
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Corresponding author

Correspondence to S. A. Kalashnikova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 151, No. 6, pp. 709–712, June, 2011

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Kalashnikova, S.A., Kovnatskaya, G.A. & Shchogolev, A.I. Morphofunctional Characteristics of the Kidneys in Chronic Endotoxemia against the Background of Hyperthyroidism. Bull Exp Biol Med 151, 761–763 (2011). https://doi.org/10.1007/s10517-011-1434-5

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  • DOI: https://doi.org/10.1007/s10517-011-1434-5

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