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Comparative Study of the Severity of Renal Damage in Newborn and Adult Rats under Conditions of Ischemia/Reperfusion and Endotoxin Administration

  • GENERAL PATHOLOGY AND PATHOPHYSIOLOGY
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Oxidative kidney injury was compared in newborn and adult rats under conditions of ischemia/reperfusion and in experimental model of systemic inflammation induced by endotoxin (LPS of bacterial cell wall) administration. Oxidative stress in the kidney accompanied both experimental models, but despite similar oxidative tissue damage, kidney dysfunction in neonates was less pronounced than in adult animals. It was found that neonatal kidney has a more potent regenerative potential with higher level of cell proliferation than adult kidney, where the level proliferating cell antigen (PCNA) increased only on day 2 after ischemia/reperfusion. The pathological process in the neonatal kidney developed against the background of active cell proliferation, and, as a result, proliferating cells could almost immediately replace the damaged structures. In the adult kidney, regeneration of the renal tissue was activated only after significant loss of functional nephrons and impairment of renal function.

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Authors and Affiliations

  1. A. N. Belozersky Research Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University, Moscow, Russia

    I. B. Pevzner, T. A. Pavlenko, V. A. Popkov, N. V. Andrianova, L. D. Zorova, S. S. Yankauskas, D. N. Silachev & D. B. Zorov

  2. V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Moscow, Russia

    I. B. Pevzner, L. D. Zorova, D. N. Silachev & D. B. Zorov

  3. Faculty of Biology, M. V. Lomonosov Moscow State University, Moscow, Russia

    A. A. Brezgunova

  4. Faculty of Bioengineering and Bioinformatics, M. V. Lomonosov Moscow State University, Moscow, Russia

    S. D. Zorov

  5. Institute of Molecular Medicine, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia

    E. Yu. Plotnikov

Authors
  1. I. B. Pevzner
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  2. T. A. Pavlenko
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  3. V. A. Popkov
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  4. N. V. Andrianova
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  5. L. D. Zorova
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  6. A. A. Brezgunova
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  7. S. D. Zorov
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  8. S. S. Yankauskas
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  9. D. N. Silachev
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  10. D. B. Zorov
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  11. E. Yu. Plotnikov
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Corresponding author

Correspondence to E. Yu. Plotnikov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 2, pp. 148-154, February, 2018

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Pevzner, I.B., Pavlenko, T.A., Popkov, V.A. et al. Comparative Study of the Severity of Renal Damage in Newborn and Adult Rats under Conditions of Ischemia/Reperfusion and Endotoxin Administration. Bull Exp Biol Med 165, 189–194 (2018). https://doi.org/10.1007/s10517-018-4127-5

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  • DOI: https://doi.org/10.1007/s10517-018-4127-5

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