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Impact of Amyloid-β Peptide (1–42) on Voltage-Gated Ion Currents in Molluscan Neurons

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Bulletin of Experimental Biology and Medicine Aims and scope

Different types of voltage-gated ion currents were recorded in isolated neurons of snail Helix pomatia using the two-microelectrode voltage-clamp technique. Application of amyloid-β peptide (1–42, 1–10 μM) in the bathing solution did not change delayed rectifier K+-current and leakage current, but enhanced inactivation of Ca2+-current and blocked Ca2+-dependent К+-current.

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Authors and Affiliations

  1. Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia

    E. I. Solntseva, J. V. Bukanova, E. V. Marchenko & V. G. Skrebitsky

Authors
  1. E. I. Solntseva
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  2. J. V. Bukanova
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  3. E. V. Marchenko
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  4. V. G. Skrebitsky
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Correspondence to E. I. Solntseva.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 151, No. 6, pp. 615–618, June 2011

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Solntseva, E.I., Bukanova, J.V., Marchenko, E.V. et al. Impact of Amyloid-β Peptide (1–42) on Voltage-Gated Ion Currents in Molluscan Neurons. Bull Exp Biol Med 151, 671–674 (2011). https://doi.org/10.1007/s10517-011-1412-y

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  • DOI: https://doi.org/10.1007/s10517-011-1412-y

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