We studied the effect of low-fluence photodynamic treatment with Photosence preparation on functional properties of macrophages and endothelium in vitro. It was shown that low-intensity photodynamic treatment did not affect viability of these cells. Exposure (0.25 J/cm2) of endothelial cells loaded with Photosence did not change the expression of adhesion molecules, but reduced adhesion of peripheral blood mononuclears to these cells. The same low-intensity exposure inhibited phagocytic activity of macrophages and reduced activity of matrix metalloproteinase-9 produced by them.
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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 2, pp. 87–91, April, 2011
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Udartseva, O.O., Andreeva, E.R., Buravkova, L.B. et al. Low-Fluence Photodynamic Treatment Modifies Functional Properties of Vascular Cell Wall. Bull Exp Biol Med 151, 521–525 (2011). https://doi.org/10.1007/s10517-011-1371-3
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DOI: https://doi.org/10.1007/s10517-011-1371-3