The time course of inflammatory reaction markers in the blood of patients with unstable angina was studied during therapy including arixtra. Plasma concentration of monocytic chemotaxic protein-1 (MCP-1) decreased on days 2 and 3 in patients receiving arixtra and a trend to an increase in MCP-1 concentration was observed on day 7 after the drug was discontinued. After 1 month, MCP-1 level decreased in all patients. The concentration of highly sensitive C-reactive protein also decreased 1 month after the disease onset; no changes in the concentrations of IL-8 and IL-2 receptor α-subunit were detected during these periods. It seems that arixtra is characterized by an anti-inflammatory effect manifesting by reduction of plasma chemokine MCP-1 concentration.
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References
N. B. Kukhtina, T. I. Arefieva, A. M. Arefieva, et al., Ter. Arkh., No. 4, 63–69 (2008).
S. I. Provatorov, T. I. Arefieva, N. B. Kukhtina, et al., Ibid., No. 6, 66–69 (2006).
M. Baggiolini, Nature, 392, 565–568 (1998).
J. W. Celie, R. H. Beelen, and J. van den Born, Front Biosci., 14, 4932–4949 (2009).
J. A. de Lemos, D. A. Morrow, M. A. Blazing, et al., J. Am. Coll. Cardiol., 50, No. 22, 2117–2124 (2007).
R. D. Frank, G. Schabbauer, T. Holscher, et al., J. Thromb. Haemost., 3, No. 3, 531–540 (2005).
C. Gonzalez-Quesada and N. G. Frangogiannis, Curr. Atheroscler. Rep., 11, No. 2, 131–138 (2009).
U. Ikeda, T. Ito, and K. Shimada, Clin. Cardiol., 24, No. 11, 701–704 (2001).
S. S. Jolly, D. P. Faxon, K. A. Fox, et al., J. Am. Coll. Cardiol., 54, No. 5, 468–476 (2009).
H. Kervinen, M. Mänttäri, M. Kaartinen, et al., Am. J. Cardiol., 94, No. 8, 993–996 (2004).
F. Mach, A. Sauty, A. S. Iarossi, et al., J. Clin. Invest., 104, No. 8, 1041–1050 (1999).
K. Olanders, A. Börjesson, X. Zhao, et al., Acta Anaesthesiol. Scand., 49, No. 4, 517–524 (2005).
A. Ozeren, M. Aydin, M. Tokac, et al., Mediators Inflamm., 12, No. 6, 361–365 (2003).
D. J. Tyrrell, A. P. Horne, K. R. Holme, et al., Adv. Pharmacol., 46, 151–208 (1999).
Y. Yu, M. D. Sweeney, O. M. Saad, et al., J. Am. Soc. Mass Spectrom., 17, No. 4, 524–535 (2006).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 150, No. 11, pp. 590–593, November, 2010
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Potekhina, A.V., Arefieva, T.I., Krasnikova, T.L. et al. Changes in the Concentration of Monocytic Chemotaxic Protein-1 in Patients with Unstable Angina Treated with Arixtra. Bull Exp Biol Med 150, 656–658 (2011). https://doi.org/10.1007/s10517-011-1215-1
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DOI: https://doi.org/10.1007/s10517-011-1215-1