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Plasma myeloperoxidase activity as a criterion of therapeutic effectiveness for patients with cardiovascular diseases

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Abstract

A significant increase in the myeloperoxidase (MPO) activity has been found in plasma of patients with stable angina and with acute coronary syndrome (ACS) in comparison with the control group. MPO concentration was significantly increased in plasma of ACS patients. Reduced MPO activity in the treated ACS patients correlated with a favorable outcome of the disease. Generally, changes in plasma MPO concentration coincided with changes in lactoferrin concentration thus confirming the role of neutrophil degranulation in the increase of plasma concentrations of these proteins. The increase in MPO activity was obviously determined by modification of the MPO protein caused by reactive oxygen species and halogen in the molar ratio of 1: 25 and 1: 50. The decrease in plasma MPO activity may be associated with increased plasma concentrations of the physiological inhibitor of its activity, ceruloplasmin, and also with modification of the MPO protein with reactive oxygen species and halogen at their molar ratio of 1: 100 and higher. Thus, MPO activity may be used for evaluation of effectiveness of the treatment of cardiovascular diseases.

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Abbreviations

ACS:

acute coronary syndrome

ELISA:

enzyme linked immunosorbent assay

IHD:

ischemic heart disease

MI:

myocardial infarction

MPO:

myeloperoxidase

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Authors and Affiliations

  1. Belarusian State University, Minsk, Belarus

    D. V. Grigorieva, I. V. Gorudko & S. N. Cherenkevich

  2. Institute for Experimental Medicine, Saint-Petersburg, Russia

    V. A. Kostevich, A. V. Sokolov & V. B. Vasilyev

  3. Research Institute of Physico-Chemical Medicine, ul. Malaya Pirogovskaya 1a, Moscow, 119435, Russia

    V. A. Kostevich, A. V. Sokolov & O. M. Panasenko

  4. Scientific and Practical Center of Hygiene, Minsk, Belarus

    I. V. Buko

  5. Scientific and Practical Center of Cardiology, Minsk, Belarus

    L. Z. Polonetsky

Authors
  1. D. V. Grigorieva
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  2. I. V. Gorudko
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  3. V. A. Kostevich
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  4. A. V. Sokolov
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  5. I. V. Buko
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  6. V. B. Vasilyev
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  7. L. Z. Polonetsky
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  8. O. M. Panasenko
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  9. S. N. Cherenkevich
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Corresponding author

Correspondence to O. M. Panasenko.

Additional information

Original Russian Text © D.V. Grigorieva, I.V. Gorudko, V.A. Kostevich, A.V. Sokolov, I.V. Buko, V.B. Vasilyev, L.Z. Polonetsky, O.M. Panasenko, S.N. Cherenkevich, 2016, published in Biomeditsinskaya Khimiya.

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Grigorieva, D.V., Gorudko, I.V., Kostevich, V.A. et al. Plasma myeloperoxidase activity as a criterion of therapeutic effectiveness for patients with cardiovascular diseases. Biochem. Moscow Suppl. Ser. B 10, 173–179 (2016). https://doi.org/10.1134/S1990750816020050

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  • DOI: https://doi.org/10.1134/S1990750816020050

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