Anti-inflammatory effects of GB-115 compound (N-phenylhexanoyl-glycyl-L-tryptophan amide) injected intraperitoneally in doses of 0.1, 1, and 10 mg/kg were demonstrated on the model of ConA- and carrageenan-induced inflammation. Intraperitoneal injection of GB-115 in a dose of 1 mg/kg to C57Bl/6 female mice with experimental autoimmune encephalomyelitis significantly alleviated the pathological symptoms, improved spontaneous locomotor activity, promoted recovery of thymus weight, and reduced edema and neutrophil infiltration of the perivascular space of the brain tissue. Intraperitoneal injection of GB-115 in a dose of 1 mg/kg suppressed generation of active oxygen forms by neutrophils in the chemiluminescence test.
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References
I. P. Ashmarin, Neirokhimiya, 24, No. 1, 3–7 (2007).
T. A. Gudasheva, E. P. Kir’yanova, L. G. Kolik, et al., Bioorg. Khim., 33, No. 4, 413–420 (2007).
L. P. Kovalenko, M. G. Miramedova, S. V. Alekseeva, et al., Eksp. Klin. Farmakol., No. 2, 53–55 (2002).
L. P. Kovalenko, E. V. Shipaeva, S. V. Alekseeva, et al., Byull. Eksp. Biol. Med., 144, No. 7, 54–57 (2007).
L. G. Kolik, T. A. Gudasheva, and S. B. Seredenin, Ibid., 135, No. 5, 519–523 (2003).
L. G. Kolik, V. N. Zhukov, and S. B. Seredenin, Eksp. Klin. Farmakol., 70, No. 2, 8–10 (2007).
Drug Register of Russia, Ed. G. L. Vyshkovskii [in Russian], Issue No. 14, Moscow (2006), P. 264.
Manual of Experimental (Preclinical) Studies of New Pharmacological Substances, Ed. R. U. Khabriev [in Russian], Moscow (2005).
S. B. Seredenin, T. A. Gudasheva, N. I. Zaitseva, et al., Byull. Izobreten., No. 11, Patent of the Russian Federation No. 2227144 (2005).
E. V. Shipaeva, L. P. Kovalenko, S. V. Khaidukov, et al., Byull. Eksp. Biol. Med., 145, No. 5, 548–551 (2008).
V. Brundula, N. B. Rewcastle, L. M. Metz, et al., Brain, 125, Pt. 6, 1297–1308 (2002).
E. J. Freireich, E. A. Gehan, D. P. Rall, et al., Cancer Chemother. Res., 50, No. 4, 219–244 (1966).
I. Tsunoda, J. E. Libbey, L. Q. Kuang, et al., Am. J. Pathol., 167, No. 61, 1631–1646 (2005).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 150, No. 11, pp. 529–532, November, 2010
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Shipaeva, E.V., Kovalenko, L.P., Sorokina, A.V. et al. Study of Anti-Inflammatory Effects of GB-115, a Glycine-Containing Retropeptide Cholecystokinin Analog. Bull Exp Biol Med 150, 599–602 (2011). https://doi.org/10.1007/s10517-011-1200-8
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DOI: https://doi.org/10.1007/s10517-011-1200-8