Skip to main content
SpringerLink
Log in

Hemostimulating Effects of Immobilized Hyaluronidase and Their Mechanisms during Cytostatic-Induced Myelosuppression

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of immobilized hyaluronidase on hemopoiesis under conditions of cyclophosphamide-induced suppression. The preparation was shown to possess high hemostimulating activity. The stimulatory effect of hyaluronidase on the erithron was more pronounced than its effect on the granulocytic hemopoietic stem due to increase in functional activity of hemopoietic precursors and hemopoiesis-inducing microenvironment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. E. D. Gol’dberg, A. M. Dygai, and G. N. Zyuz’kov, Hypoxia and Blood System [in Russian], Tomsk (2006).

  2. E. D. Gol’dberg, A. M. Dygai, G. N. Zyuz’kov, et al., Byull. Eksp. Biol. Med., 144, No. 12, 652–656 (2007).

    Google Scholar 

  3. E. D. Gol’dberg, A. M. Dygai, G. N. Zyuz’kov, et al., Kletochn. Tekhnol. Biol. Med., No. 2, 115–119 (2007).

  4. E. D. Gol’dberg, A. M. Dygai, and V. P. Shakhov, Tissue Culture Methods in Hematology [in Russian], Tomsk (1992).

  5. A. M. Dygai, E. I. Vereschagin, G. N. Zyuz’kov, et al., Kletochn. Tekhnol. Biol. Med., No. 2, 63–66 (2009).

  6. G. N. Zyuz’kov, V. V. Zhdanov, A. M. Dygai, and E. D. Gol’dberg, Byull. Eksp. Biol. Med., 144, No. 12, 690–695 (2007).

    Google Scholar 

  7. Laboratory Methods of Studies in Clinical Practice [in Russian], Ed. V. V. Men’shikov, Moscow (1987).

  8. G. F. Lakin, Biometry [in Russian], Moscow (1973).

  9. F. Gao, P. Okunieff, Z. Han, et al., Adv. Exp. Med. Biol., 566, 249–256 (2005).

    Article  CAS  PubMed  Google Scholar 

  10. S. Nedvetzki, E. Gonen, N. Assayang, et al., Proc. Natl. Acad. Sci. USA, 101, No. 52, 18,081–18,086 (2004).

    Article  CAS  Google Scholar 

  11. P. W. Noble, Matrix Biol., 21, No. 1, 25–29 (2002).

    Article  CAS  PubMed  Google Scholar 

  12. R. Stern, Glycobiology, 13, No. 12, 105R–115R (2003).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    A. M. Dygai, V. V. Zhdanov, G. N. Zyuz’kov, E. V. Udut, T. Yu. Khrichkova, E. V. Simanina, L. A. Stavrova, L. A. Miroshnichenko & A. V. Chaikovskiy

  2. Scientific Features Management Company, Novosibirsk, Russia

    A. V. Artamonov, A. A. Bekarev, E. I. Vereschagin & P. G. Madonov

Authors
  1. A. M. Dygai
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. V. Artamonov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. A. Bekarev
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. I. Vereschagin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V. V. Zhdanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. G. N. Zyuz’kov
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. E. V. Udut
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. T. Yu. Khrichkova
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. E. V. Simanina
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. L. A. Stavrova
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. L. A. Miroshnichenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. A. V. Chaikovskiy
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. P. G. Madonov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. M. Dygai.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 5, pp. 528-531, May, 2010

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dygai, A.M., Artamonov, A.V., Bekarev, A.A. et al. Hemostimulating Effects of Immobilized Hyaluronidase and Their Mechanisms during Cytostatic-Induced Myelosuppression. Bull Exp Biol Med 149, 594–597 (2010). https://doi.org/10.1007/s10517-010-1001-5

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-010-1001-5

Key Words

Search

Navigation