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Hemostimulating Effects of Immobilized Hyaluronidase and Their Mechanisms during Cytostatic-Induced Myelosuppression

Bulletin of Experimental Biology and Medicine volume 149, pages 594–597 (2010)Cite this article

We studied the effect of immobilized hyaluronidase on hemopoiesis under conditions of cyclophosphamide-induced suppression. The preparation was shown to possess high hemostimulating activity. The stimulatory effect of hyaluronidase on the erithron was more pronounced than its effect on the granulocytic hemopoietic stem due to increase in functional activity of hemopoietic precursors and hemopoiesis-inducing microenvironment.

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Authors and Affiliations

  1. Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    A. M. Dygai, V. V. Zhdanov, G. N. Zyuz’kov, E. V. Udut, T. Yu. Khrichkova, E. V. Simanina, L. A. Stavrova, L. A. Miroshnichenko & A. V. Chaikovskiy

  2. Scientific Features Management Company, Novosibirsk, Russia

    A. V. Artamonov, A. A. Bekarev, E. I. Vereschagin & P. G. Madonov

Authors
  1. A. M. Dygai
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  2. A. V. Artamonov
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  3. A. A. Bekarev
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  4. E. I. Vereschagin
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  5. V. V. Zhdanov
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  6. G. N. Zyuz’kov
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  7. E. V. Udut
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  8. T. Yu. Khrichkova
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  9. E. V. Simanina
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  10. L. A. Stavrova
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  11. L. A. Miroshnichenko
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  12. A. V. Chaikovskiy
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  13. P. G. Madonov
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Corresponding author

Correspondence to A. M. Dygai.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 5, pp. 528-531, May, 2010

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Dygai, A.M., Artamonov, A.V., Bekarev, A.A. et al. Hemostimulating Effects of Immobilized Hyaluronidase and Their Mechanisms during Cytostatic-Induced Myelosuppression. Bull Exp Biol Med 149, 594–597 (2010). https://doi.org/10.1007/s10517-010-1001-5

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  • DOI: https://doi.org/10.1007/s10517-010-1001-5

Key Words

  • myelosuppression
  • immobilized hyaluronidase
  • erythropoiesis
  • granulocytopoiesis