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Role of Hemopoietic Precursors of Various Classes in the Effect of Granulocyte Colony-Stimulating Factor on Hemopoiesis during Cytostatic-Induced Myelosuppression

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Experiments were performed on the model of cyclophosphamide-induced myelosuppression. We showed that regeneration of the granulocytic hemopoietic stem is related to activation of multipotent, granulocyte-erythroid-macrophage-megakaryocyte, and granulocyte-macrophage precursors. The division and maturation of granulocyte colony-forming cells and significant decrease in the number of these cells in the bone were suppressed under these conditions. The granulocytopoiesis-stimulating effect of granulocyte CSF during myelosuppression was associated with an increase in functional activity of multipotent and granulocyte-erythroidmacrophage-megakaryocyte precursors (primarily of differentiation). In the period of regeneration, this effect was attributed to activity of granulocyte precursors.

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Authors and Affiliations

  1. Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    A. M. Dygai, E. G. Skurikhin, O. V. Pershina, T. V. Andreeva, E. S. Khmelevskaya & M. Ju. Minakova

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  1. A. M. Dygai
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  2. E. G. Skurikhin
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  3. O. V. Pershina
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  4. T. V. Andreeva
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  5. E. S. Khmelevskaya
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  6. M. Ju. Minakova
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Corresponding author

Correspondence to A. M. Dygai.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 4, pp. 400–404, April, 2010

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Dygai, A.M., Skurikhin, E.G., Pershina, O.V. et al. Role of Hemopoietic Precursors of Various Classes in the Effect of Granulocyte Colony-Stimulating Factor on Hemopoiesis during Cytostatic-Induced Myelosuppression. Bull Exp Biol Med 149, 416–420 (2010). https://doi.org/10.1007/s10517-010-0959-3

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  • DOI: https://doi.org/10.1007/s10517-010-0959-3

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