Morphology and function of the major salivary glands were studied in 50 albino rats drinking water supplemented with aluminum chloride for 2 weeks. Against the background of normal gland appearance, the salivation function and the composition of the saliva were changed: the concentrations of sodium and calcium ions and α-amylase activity were reduced. In parallel, cholesterol content was increased by 54%.
Similar content being viewed by others
References
O. P. Bol’shakov, N. G. Neznanov, and R. V. Babakhanyan, Kach. Klin. Pract., No. 1, 24-28 (2002).
G. M. Vishnevskaya and T. M. Lyashevskaya, Lab. Delo., No. 7, 444-446 (1976).
A. B. Denisov, Saliva. Salivary Glands [In Russian], Moscow (2006), p. 63.
M. I. Nekipelov. Microelements in Medicine, Eds. M. G. Kolomiytsev, G. D. Gabovich [In Russian], Moscow (1970), pp. 133-136.
Guidelines for Preclinical Assessment of the Safety of Pharmacological Agent (GLP) [In Russian], RD -- 64-126-91. Moscow (1992).
C. L. Crocker, Am. J. Med. Technol., 33, No. 5, 361-365 (1967).
J. Fischer and J. Tovarek, Clin. Chem., 31, 166 (1975).
A. Graczyk, K. Radomska, and M. Dlugaszek, Synergizm i antagonizm między biopierwiastkami i metalami toksycznymi. Ochrona Srodowiska i Zasobow Naturalych nr 18. Instytut Ochrony Srodowiska. Warszawa, No. 18, 39-45 (1999).
H. O. Hellstrom, B. Mjoberg, H. Mallmin, and K. Michaelsson, Osteoporos. Int., 16, No. 12, 1982-1988 (2005).
E. Holzle and and O. Braun-Falco, Br. J. Dermatol., 110, No. 4, 399-403 (1984).
S. Ilca, Zschr. Ges. Inn. Med., B. 17, H2. S. 83 (1962).
G. N. Krasovskii, L. Y. Vasukovich, and O. G. Chariev, Environ. Health Perspect., 30, 47-51 (1979).
S. Reitman and S. Frankel, Am. J. Clin. Pathol., 28, No. 1, 56-63 (1957).
R. J. Ward and Y. Zhang, and R. R. Crichton, J. Inorg. Biochem., 87, Nos. 1-2, 9-14 (2001).
R. Viestra and A. Haug, Biochem. Biophys. Res. Commun., 84, No. 1, 138-143 (1978).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 148, No. 12, pp. 703-706, December, 2009
Rights and permissions
About this article
Cite this article
Denisov, A.B. Morphological and Functional State of Major Salivary Glands under Conditions of Aluminum Chloride Excess in Drinking Water. Bull Exp Biol Med 148, 940–942 (2009). https://doi.org/10.1007/s10517-010-0857-8
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-010-0857-8