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Mechanisms of Toxic Effect of Streptozotocin on β-Cells in the Islets of Langerhans

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Bulletin of Experimental Biology and Medicine Aims and scope

Administration of streptozotocin caused selective damage to endocrine β-cells in rat pancreatic islets, which was related to activation of apoptosis. The cytotoxic effect of streptozotocin was associated not only with DMA damage due to dysfunction of the antioxidant defense system, but also with activation of the caspase cascade and TNF-related apoptosis-inducing ligand.

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Authors and Affiliations

  1. Department of Pathological Anatomy, Moscow, Russia

    V. B. Pisarev & G. L. Snigur

  2. Department of Pharmacology, Volgograd State Medical University, Volgograd, Russia

    A. A. Spasov & M. P. Samokhina

  3. Russian Research Institute of Health, Moscow, Russia

    A. E. Bulanov

Authors
  1. V. B. Pisarev
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  2. G. L. Snigur
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  3. A. A. Spasov
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  4. M. P. Samokhina
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  5. A. E. Bulanov
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Corresponding author

Correspondence to G. L. Snigur.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 148, NV: 12, pp. 700-702, December, 2009

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Pisarev, V.B., Snigur, G.L., Spasov, A.A. et al. Mechanisms of Toxic Effect of Streptozotocin on β-Cells in the Islets of Langerhans. Bull Exp Biol Med 148, 937–939 (2009). https://doi.org/10.1007/s10517-010-0856-9

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  • DOI: https://doi.org/10.1007/s10517-010-0856-9

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