Experiments on the model of paired sensory contact demonstrated that stimulation of immune response in aggressive CBA and C57Bl/6J mice with 10- and 20-day experience of victories, respectively, was prevented by selective δ2-opioid receptor agonists DSLET and κ-opioid receptor agonists rimorphin in a dose of 100 μg/kg. In C57Bl/6J mice with depression-like behavior, normalization (but not suppression) of the immune response under conditions of μ-opioid receptor stimulation (100 μg/kg) was observed. Selective modulation of activity of a certain type of opioid receptors can normalize the immune function modifi ed during the formation of a certain behavioral type.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 148, No. 12, pp. 646-648, December, 2009
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Cheido, M.A., Idova, G.V. Immune Response of Submissive and Aggressive Mice under Conditions of Opioid Receptor Activation. Bull Exp Biol Med 148, 886–888 (2009). https://doi.org/10.1007/s10517-010-0843-1
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DOI: https://doi.org/10.1007/s10517-010-0843-1