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Antiulcer Activity of Preparations Containing Ultralow Doses of Antibodies in Modeled Chronic Ulcer in Rats

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Bulletin of Experimental Biology and Medicine Aims and scope

Screening of three potential antiulcer preparations containing ultralow doses of antibodies to endogenous regulators of ulcer formation (gastrin, histamine, and H2 histamine receptors) on the model of acetic acid-induced gastric ulcer in rats revealed pronounced antiulcer effect of ultralow doses of antibodies to histamine. The dynamics of regeneration of the ulcer focus by morphological and histological characteristics was similar during treatment with ultralow doses of antibodies to histamine and with famotidine.

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Authors and Affiliations

  1. N. N. Vorozhtsov Institute of Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia

    T. G. Tolstikova, N. A. Zhukova, I. V. Sorokina, M. P. Dolgikh, T. V. Ogorodnikova, M. V. Borodavkina, Yu. L. Dugina & S. A. Sergeeva

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  1. T. G. Tolstikova
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  2. N. A. Zhukova
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  3. I. V. Sorokina
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  4. M. P. Dolgikh
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  5. T. V. Ogorodnikova
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  6. M. V. Borodavkina
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  7. Yu. L. Dugina
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  8. S. A. Sergeeva
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Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 148, Suppl. 1, pp. 181-183, September, 2009

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Tolstikova, T.G., Zhukova, N.A., Sorokina, I.V. et al. Antiulcer Activity of Preparations Containing Ultralow Doses of Antibodies in Modeled Chronic Ulcer in Rats. Bull Exp Biol Med 148, 540–542 (2009). https://doi.org/10.1007/s10517-010-0759-9

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  • DOI: https://doi.org/10.1007/s10517-010-0759-9

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