3-Hydroxyimino derivatives of minor licorice triterpenoids possessed pronounced antiulcer activity and protected rat gastric mucosa from ulceration in indomethacin and orthophen ulcer models at a dose of 50 mg/kg. 3-Hydroxyimino-11-deoxoglycyrrhetic acid was the most active antiulcerogenic substance and was superior in activity to carbenoxolone.
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The work was performed on topics of State Tasks AAAA-A20-120012090026-9 and 1021062311395-6-1.4.1 and used equipment at the Khimiya CUC.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 56, No. 2, pp. 21 – 24, February, 2022.
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Baltina, L.A., Sapozhnikova, T.A., Khisamutdinova, R.Y. et al. Antiulcer Activity of 3-Hydroxyimino Derivatives of Minor Triterpenoids of Licorice Root. Pharm Chem J 56, 163–166 (2022). https://doi.org/10.1007/s11094-022-02619-w
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DOI: https://doi.org/10.1007/s11094-022-02619-w