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Time Course of Expression of “Early” Genes during Long-Term Posttetanic Potentiation in Rat Hippocampal CA1 Field

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The expression of egr-1, junB, c-jun, and c-fos genes in rat hippocampal CA1 fi eld was studied by the real-time PCR 30, 60, and 120 min after induction of long-term posttetanic potentiation. The content of egr-1, junB, and c-jun mRNA gradually increased and doubled 120 min after tetanization. The increase in c-jun mRNA level lagged behind the increment of egr-1 and junB. The level of c-fos mRNA increased 30 min after tetanization, returned to the initial level by min 60, and again increased 120 min after induction of long-term posttetanic potentiation.

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Authors and Affiliations

  1. Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    O. O. Sokolova, M. B. Shtark & V. O. Pustyl’nyak

  2. Designing and Technological Institute of Computer Engineering, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    P. D. Lisachev

  3. Materia Medica Holding, Moscow, Russia

    I. V. Pan

Authors
  1. O. O. Sokolova
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  2. M. B. Shtark
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  3. P. D. Lisachev
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  4. V. O. Pustyl’nyak
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  5. I. V. Pan
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Corresponding author

Correspondence to M. B. Shtark.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 148, No. 9, pp. 304-306, September, 2009

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Sokolova, O.O., Shtark, M.B., Lisachev, P.D. et al. Time Course of Expression of “Early” Genes during Long-Term Posttetanic Potentiation in Rat Hippocampal CA1 Field. Bull Exp Biol Med 148, 416–418 (2009). https://doi.org/10.1007/s10517-010-0726-5

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  • DOI: https://doi.org/10.1007/s10517-010-0726-5

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