We studied the effects of cholesterol, its oxidized derivatives mevalonate, and nuclear receptor agonists LXR, RXR, and FXR on the production of transforming growth factor-β1 (TGF- β1) by macrophages. After recruiting of macrophage monocytes into the focus of infl ammation, the production of TGF-β1 increased by 3.5 times in comparison with control macrophages. Cholesterol diet stimulated the production of TGF-β1 by 2.5 times. Cholesterol directly stimulated macrophage production of TGF-β1 in vitro, while addition of mevalonate to the incubation medium effectively reduced this induced production. Agonists of nuclear receptor sharply reduced the production of TGF-β1 in recruited macrophages. Under conditions of infl ammation, hypercholesterolemia can be a factor of fi brogenesis due to TGF-β1 induction in macrophages, which depends on the products of mevalonate biochemical chain.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 148, No. 9, pp. 294-297, September, 2009
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Schwartz, Y.S., Khoshchenko, O.M., Dushkin, M.I. et al. Effects of Cholesterol and Nuclear Hormone Receptor Agonists on the Production of Transforming Growth Factor-β in Macrophages. Bull Exp Biol Med 148, 406–409 (2009). https://doi.org/10.1007/s10517-010-0724-7
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DOI: https://doi.org/10.1007/s10517-010-0724-7