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Cholesterol-induced stimulation of postinflammatory liver fibrosis

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Abstract

We studied the effect of high-cholesterol diet and factors inhibiting 3-hydroxy-3-methyl-glutaryl coenzyme A reductase on the development of liver fibrosis in C57Bl/6 mice with CCl4-or zymosan-induced hepatitis. Feeding a high-cholesterol diet led to a sharp increase in collagen content in the liver tissue of animals with CCl4-induced or zymosan-induced hepatitis. Atorvastatin and calcitriol produced less pronounced fibrogenic effects. Mevalonate partially prevented the development of cholesterol-induced fibrogenesis. High-cholesterol diet led to accumulation of oxysterols, cholesterol esters, and triglycerides and increased the expression of transforming growth factor-β1 mRNA in liver tissue. Cholesterol-induced potentiation of the fibrogenic response is probably associated with transforming growth factor-β1 induction due to accumulation of lipids and oxysterols in the liver.

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Authors and Affiliations

  1. Institute of Therapy, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    Y. Sh. Schwartz, M. I. Dushkin, N. I. Komarova, E. V. Vorontsova & I. S. Kuznetsova

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  1. Y. Sh. Schwartz
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  2. M. I. Dushkin
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  3. N. I. Komarova
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  4. E. V. Vorontsova
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  5. I. S. Kuznetsova
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Correspondence to Y. Sh. Schwartz.

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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 145, No. 6, pp. 638–641, June, 2008

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Schwartz, Y.S., Dushkin, M.I., Komarova, N.I. et al. Cholesterol-induced stimulation of postinflammatory liver fibrosis. Bull Exp Biol Med 145, 692–695 (2008). https://doi.org/10.1007/s10517-008-0175-6

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  • DOI: https://doi.org/10.1007/s10517-008-0175-6

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