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Parameters of the Cytokine System Functioning in Laboratory Primates

  • Primatology
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Bulletin of Experimental Biology and Medicine Aims and scope

The cytokine status (IFN, IL, etc.) of different monkey species (M. mulatta, P. hamadryas, C. aethiops) was studied. The interferon status is determined by the following parameters: IFN content in circulating blood and production of IFN-α and IFN-γ by lymphocytes after appropriate in vitro induction. The interferon status of monkeys is similar to that of humans. The capacity to produce IFN reduces with age. It was found that genes of virtually all studied cytokines are expressed in blood cells and hence, in immune system cells.

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Authors and Affiliations

  1. Institute of Medical Primatology, the Russian Academy of Medical Sciences, Sochi, Russia

    V. Z. Agrba, B. A. Lapin, D. D. Karal-ogly, I. E. Ignatova, A. A. Agumava & N. A. Aphanasiev

  2. N. F. Gamaleya Institute of Epidemiology and Microbiology, the Russian Academy of Medical Sciences, Moscow, Russia

    M. V. Mezentseva, I. M. Surgutcheva & V. E. Sherbenko

Authors
  1. V. Z. Agrba
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  2. B. A. Lapin
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  3. M. V. Mezentseva
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  4. D. D. Karal-ogly
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  5. I. M. Surgutcheva
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  6. I. E. Ignatova
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  7. V. E. Sherbenko
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  8. A. A. Agumava
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  9. N. A. Aphanasiev
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Corresponding author

Correspondence to B. A. Lapin.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 148, No. 8, pp. 223–225, August, 2009

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Agrba, V.Z., Lapin, B.A., Mezentseva, M.V. et al. Parameters of the Cytokine System Functioning in Laboratory Primates. Bull Exp Biol Med 148, 250 (2009). https://doi.org/10.1007/s10517-009-0708-7

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  • DOI: https://doi.org/10.1007/s10517-009-0708-7

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