Simulation of chronic heart failure in rats led to an increase in heart rate variability and decrease in heart rate. All β-blockers also promoted the heart rate variability augmentation in ill animals. The most potent effects on heart rate variability were produced by pindolol, atenolol, and propranolol. Bisoprolol and metoprolol affected heart rate and heart rate variability in less extent, and nebivolol normalized a part of heart rate variability parameters.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 147, No. 2, pp. 139–143, February, 2009
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Sal’nikov, E.V. Heart Rate Variability in Rats with Experimental Chronic Heart Failure and Long-Term Exposure to β-Adrenoblockers. Bull Exp Biol Med 147, 181–184 (2009). https://doi.org/10.1007/s10517-009-0466-6
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DOI: https://doi.org/10.1007/s10517-009-0466-6