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Role of Phospholipase A2 in Activation of Isolated Cardiomyocyte Respiration in Postinfarction Cardiosclerosis

  • General Pathology and Pathophysiology
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Bulletin of Experimental Biology and Medicine Aims and scope

The rate of oxygen consumption by isolated cardiomyocytes was studied in rats with experimental postinfarction cardiosclerosis. The increase in oxygen consumption under these condition was comparable to that in melittin- and arachidonic acid-induced activation of phospholipase A2 in cardiomyocytes of intact animals. Bromophenacyl bromide inhibition of phospholipase A2 in cardiomyocytes of rats with postinfarction cardiosclerosis led to reduction of oxygen consumption rate to values characteristic of intact animal cardiomyocytes. The results confirm the hypothesis according to which high oxygen consumption in postinfarction cardiosclerosis is related to increased activity of phospholipase A2.

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References

  1. N. N. Brustovetskii, M. V. Egorova, V. G. Gogvadze, et al., Biol. Membrany, 8 No. 9, 907–911 (1991).

    CAS  Google Scholar 

  2. M. V. Egorova, S. A. Afanasyev, and S. V. Popov, Byull. Eksp. Biol. Med., 140 No. 9, 357–360 (2005).

    Google Scholar 

  3. D. S. Kondratyeva, S. A. Afanasyev, L. P. Falaleeva, and V. P. Shakhov, Ibid., 140 No. 6, 613–616 (2005).

    Google Scholar 

  4. L. D. Luk’yanova, Vestn. Rossiisk. Akad. Med. Nauk, No. 9, 3–12 (2000).

  5. S. N. Molchanov, S. A. Lyusov, A. V. Govorin, and I. V. Neverov, Ros. Kardiol. Zh., No. 2, 10–17 (2005).

  6. A. Grynberg, Medikografiya, 21 No. 2, 29–38 (1999).

    Google Scholar 

  7. S. Neubauer, M. Horn, A. Naumann, et al., J. Clin. Invest., 95 No. 3, 1092–1100 (1995).

    Article  PubMed  CAS  Google Scholar 

  8. M. F. Oliver and L. H. Opie, Lancet, 343, 155–158 (1994).

    Article  PubMed  CAS  Google Scholar 

  9. G. J. Van der Vusse, R. S. Renemann, and M. Van Bilsen, Prostaglandins Leukot. Essent. Fatty Acids, 57 No. 1, 85–93 (1997).

    Article  PubMed  Google Scholar 

  10. G. J. Van der Vusse, J. F. Glatz, H. C. Stam, and R. S. Renemann, Physiol. Rev., 72 No. 4, 881–940 (1992).

    PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Institute of Cardiology, Tomsk Research Center, Russian Academy of Medical Sciences, Tomsk, Russia

    M. V. Egorova, S. A. Afanas’ev & S. V. Popov

Authors
  1. M. V. Egorova
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  2. S. A. Afanas’ev
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  3. S. V. Popov
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Corresponding author

Correspondence to M. V. Egorova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 146, No. 12, pp. 631–633, December, 2008

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Egorova, M.V., Afanas’ev, S.A. & Popov, S.V. Role of Phospholipase A2 in Activation of Isolated Cardiomyocyte Respiration in Postinfarction Cardiosclerosis. Bull Exp Biol Med 146, 695–697 (2008). https://doi.org/10.1007/s10517-009-0398-1

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  • DOI: https://doi.org/10.1007/s10517-009-0398-1

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