Lipopolysaccharide toxin added to primary hepatocyte culture slightly modified the basal concentrations of 3H-serine-labeled sphingomyelin, sphingosine, and ceramide. Ethanol reduced the levels of sphingomyelin and sphingosine by 20–25 and 15–20%, respectively, but increased ceramide content by 7–17%. Tumor necrosis factor reduced the concentrations of sphingomyelin and sphingosine, but did not modify the content of ceramide. Combined treatment with lipopolysaccharide toxin and ethanol potentiated the effect of alcohol.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 146, No. 12, pp. 660-662, December, 2008
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Viktorov, A.V., Yurkiv, V.A. Effects of Ethanol and Lipopolysaccharide on the Sphingomyelin Cycle in Rat Hepatocytes. Bull Exp Biol Med 146, 753–755 (2008). https://doi.org/10.1007/s10517-009-0379-4
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DOI: https://doi.org/10.1007/s10517-009-0379-4