A mixture of mitochondrial substrates of succinic and malic acids more effectively than antihypoxant trimetazidine prevented functional and metabolic disorders in rat myocardium during acute ischemia: reduces T wave amplitude, QT interval, number and duration of arrhythmias, and restores oxidation-phosphorylation coupling.
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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 146, No. 8, pp. 183–187, August, 2008
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Khazanov, V.A., Kiseliova, A.A., Vasiliev, K.Y. et al. Cardioprotective effects of trimetazidine and a combination of succinic and malic acids in acute myocardial ischemia. Bull Exp Biol Med 146, 218–222 (2008). https://doi.org/10.1007/s10517-008-0259-3
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DOI: https://doi.org/10.1007/s10517-008-0259-3