Flavonoid-containing plant preparations (water soluble extracts of Pentaphylloides fruticosa [Extralife], Emblica officinalis Gaerth [Amla], and Bergenia crassifolia [Bergenia]) produced a dose-dependent and tissue-specific effect on activity of mitochondrial ATP-dependent potassium channel. The effect of these preparations was biphasic (activation and inhibition). The activating effect of Extralife was one order of magnitude higher than that of Amla and Bergenia and was observed in a wider concentration range. The activating effect of preparations was abolished by inhibitors of the mitochondrial ATP-dependent potassium channel, which attested to specificity of their influence on mitochondrial channel. Under in vivo conditions, the antihypoxic effect of Extralife was partially abolished by mitochondrial ATP-dependent potassium channel inhibitor 5-hydroxydecanoate.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
O. V. Baranova, Yu. Yu. Skarga, A. E. Negoda, and G. D. Mironova, Biokhimiya, 65, No. 2, 262–267 (2000).
L. D. Luk'yanova, E. L. Germanova, and A. I. Lysko, Vestn. Ros. Akad. Med. Nauk, No. 2, 55–62 (2007).
G. D. Mironova, E. V. Kachaeva, and A. T. Kopylov, Ibid., No. 2, 34–50 (2007).
R. Bajgar, S. Steetharaman, A. J. Kowaltowski, et al., J. Biol. Chem., 276, No. 36, 33,369–33,374 (2001).
J. W. Jr. Erdman, D. Balentine, L. Arab., et al., J. Nutr., 137, No. 3, Suppl. 1, 718S–737S (2007).
K. D. Garlid, P. Paucek, V. Yarov-Yarovoy, et al., Circ. Res., 81, No. 6, 1072–1082 (1997).
K. D. Garlid and P. Paucek, Biochim. Biophys. Acta, 1606, Nos. 1–3, 23–41 (2003).
I. B. Krylova, E. V. Kachaeva, O. M. Rodionova, et al., Exp. Gerontol., 41, No. 7, 697–703 (2006).
P. K. Mukherjee, Drug Inf. J., 35, 623–632 (2001).
E. Jr. Middleton, C. Kandaswami, and C. Theoharides, Pharmacol. Rev., 52, No. 4, 673–751 (2000).
G. D. Mironova, A. E. Negoda, B. S. Marinov, et al., J. Biol. Chem., 279, No. 31, 32,562–32,568 (2004).
B. O'Rourke, Circ. Res., 94, No. 4, 420–432 (2004).
S. V. Popov, G. Y. Popova, S. Y. Nikolaeva, et al., Phytother. Res., 19, No. 12, 1052–1056 (2005).
Y. Wang, M. Kudo, M. Xu, et al., J. Mol. Cell Cardiol., 33, No. 11, 2037–2046 (2001).
R. J. Williams, J. P. Spencer, and C. Rice-Evans, Free Radic. Biol. Med., 36, No. 7, 838–849 (2004).
Author information
Authors and Affiliations
Additional information
Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 146, No. 8, pp. 195–199, August, 2008
Rights and permissions
About this article
Cite this article
Mironova, G.D., Shigaeva, M.I., Belosludtseva, N.V. et al. Effect of several flavonoid-containing plant preparations on activity of mitochondrial ATP-dependent potassium channel. Bull Exp Biol Med 146, 229–233 (2008). https://doi.org/10.1007/s10517-008-0255-7
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-008-0255-7