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Effects of synthetic and plant-derived selective modulators of estrogen receptors on depression-like behavior of female rats

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

Effects of chronic (for 14 days) intramuscular injections of tamoxifen (10 mg/kg), klimadynon (Cimicifuga extract; 20 mg/kg), and genistein (10 mg/kg) on depressionlike state were studied in female rats under conditions of natural fluctuations of blood estrogen levels and ovariectomy. Chronic tamoxifen caused a pronounced depression, while chronic klimadynon and genistein exhibited a pronounced antidepressant effect in intact and ovariectomized rats.

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Authors and Affiliations

  1. S. V. Anichkov Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg, Russia

    N. S. Sapronov & S. B. Kasakova

Authors
  1. N. S. Sapronov
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  2. S. B. Kasakova
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Correspondence to S. B. Kasakova.

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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 146, No. 7, pp. 80–83, July, 2008

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Sapronov, N.S., Kasakova, S.B. Effects of synthetic and plant-derived selective modulators of estrogen receptors on depression-like behavior of female rats. Bull Exp Biol Med 146, 73–76 (2008). https://doi.org/10.1007/s10517-008-0210-7

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  • DOI: https://doi.org/10.1007/s10517-008-0210-7

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