The dynamics of hypokinesia in male C57Bl/6 mice induced by single administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine was studied on the model of parkinsonian syndrome. The neurochemical effect of this neurotoxin was evaluated at the peak of locomotor disorders. Severe hypokinesia was accompanied by an increase in serotonin content and decrease in the rate of serotonin biodegradation in the striatum, hippocampus, and frontal cortex. The content of dopamine metabolite 3,4-dihydroxyphenylacetic acid and dopamine turnover decreased in the striatum, but increased in the hippocampus and frontal cortex. Norepinephrine content decreased in the hypothalamus and cortex. Aspartate content decreased in the hypothalamus and hippocampus.
Similar content being viewed by others
References
E. A. Val'dman, T. A. Voronina, and L. N. Nerobkova, Eksper. Klin. Farmakol., No. 4, 3–7 (1999).
G. N. Kryzhanovskii, I. N. Karaban', S. V. Magaeva, et al., Parkinson's Disease [in Russian], Moscow (2002), pp. 33–59.
V. S. Kudrin, I. I. Miroshnichenko, and K. S. Raevskii, Neirokhimiya, 7, No. 1, 3–8 (1988).
N. N. Lermontova, L. S. Solyakov, S. O. Bachurin, et al., Byull. Eksp. Biol. Med., 110, No. 10, 397–399 (1990).
T. Araki, T. Mikami, H. Tanji, et al., Eur. J. Pharm. Sci., 12, 231–238 (2001).
R. E. Heikkila, A. Hess, and R. C. Duvoisin, Science, 224, 1451–1453 (1984).
S. J. Pearson, C. Czudek, K. Mercer, and G. P. Reynolds, J. Neuronal Transm., 86, 151–157 (1991).
T. L. Perry, V. W. Yong, K. Jones, et al., Neurosci. Lett., 58, 321–326 (1985).
J. C. Perry, D. C. Hipolide, S. Tufik, et al., Exper. Neurol., 195, 322–329 (2005).
S. Przedborski and M. Vila, Ann. N. Y. Acad. Sci. (United States), 991, 189–198 (2003).
M. Sedelis, R. K. W. Schwarting, and J. P. Huston, Behav. Brain Res., 125, 109–125 (2001).
J. L. Tillerson, W. M. Caudle, M. E. Reveron, et al., Exp. Neurol., 178, 80–90 (2002).
X. Shan, L. Chi, M. Bishop, et al., Stem Cells, 24, No. 5, 1280–1287 (2006).
W. Zhang, E-J. Shin, T. Wang, et al., The FASEB J., 20, 2496–2511 (2006).
M. Zhao, S. Momma, K. Delfani, et al., PNAS, 100, No. 13, 7925–7930 (2003).
Author information
Authors and Affiliations
Corresponding author
Additional information
__________
Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 146, No. 7, pp. 58–61, July, 2008
Rights and permissions
About this article
Cite this article
Kapitza, I.G., Kalinina, T.S., Nerobkova, L.N. et al. Relationship between the severity of hypokinesia induced by neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and neurochemical changes in brain structures of C57Bl/6 mice. Bull Exp Biol Med 146, 52–55 (2008). https://doi.org/10.1007/s10517-008-0204-5
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-008-0204-5