Abstract
We studied the capacity of anomeric pairs of α-and β-dodecyl, α-and β-(1-pentylhexyl), and α-and β-cyclododecyl glycosides of N-acetylmuramyl-L-alanyl-D-isoglutamine (muramyl dipeptide) to stimulate the nonspecific resistance of mice to intraperitoneal infection of Staphylococcus aureus and Escherichia coli cultures. Intraperitoneal pre-treatment with the test substances in a wide dose range increased survival of infected animals. No differences were found between the biological effects of α-and β-dodecyl and α-and β-(1-pentylhexyl) glycosides of muramyl dipeptide. An inverse relationship was found between stimulatory activity and dose of α-and β-cyclododecyl glycosides of muramyl dipeptide during sepsis caused by Staphylococcus aureus.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 5, pp. 561–564, May, 2008
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Kalyuzhin, O.V., Zemlyakov, A.E., Kalina, N.G. et al. Biological activity of anomeric pairs of lipophilic glycosides of N-acetylmuramyl-L-alanyl-D-isoglutamine. Bull Exp Biol Med 145, 623–625 (2008). https://doi.org/10.1007/s10517-008-0157-8
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DOI: https://doi.org/10.1007/s10517-008-0157-8