Abstract
The production and role of autoantibodies against neurotransmitters glutamate, γ-aminobutyric acid, and norepinephrine were studied in rats with experimental neuropathic pain syndrome induced by sciatic nerve transection. Nerve transection in rats was followed by behavioral reaction of autotomy (self-mutilation of the operated limb), which often accompanies neuropathic pain syndrome. The development of neuropathic pain syndrome was accompanied by increased production of autoantibodies against glutamate, γ-aminobutyric acid, and norepinephrine. A negative correlation was found between the amount of autoantibodies against neurotransmitters and severity of neuropathic pain syndrome. Our results suggest that antibodies against glutamate and norepinephrine exhibit protective activity.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 5, pp. 521–524, May, 2008
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Evseev, V.A., Vetrile, L.A., Smirnova, V.S. et al. Autoantibodies against glutamate, γ-aminobutyric acid, and norepinephrine in mechanisms of neuropathic pain syndrome. Bull Exp Biol Med 145, 584–587 (2008). https://doi.org/10.1007/s10517-008-0141-3
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DOI: https://doi.org/10.1007/s10517-008-0141-3