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Effect of tetrapeptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on the structure and function of the thyroid gland in neonatally hypophysectomized chickens

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Abstract

Tetrapeptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly were synthesized on the basis of amino acid composition of pituitary cytomedins. Administration of these tetrapeptides to hypophysectomized chickens for 40 days was followed by an increase in the concentrations of thyrotropic hormone and thyroid hormones and recovery of thyroid gland structure.

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Authors and Affiliations

  1. Department of Normal Physiology, Chita State Medical Academy, Chita, Russia

    B. I. Kuznik, A. V. Pateyuk & N. S. Rusaeva

  2. Department of Histology, Chita State Medical Academy, Chita, Russia

    B. I. Kuznik, A. V. Pateyuk & N. S. Rusaeva

Authors
  1. B. I. Kuznik
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  2. A. V. Pateyuk
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  3. N. S. Rusaeva
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Corresponding author

Correspondence to B. I. Kuznik.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 1, pp. 111–114, January, 2008

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Kuznik, B.I., Pateyuk, A.V. & Rusaeva, N.S. Effect of tetrapeptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on the structure and function of the thyroid gland in neonatally hypophysectomized chickens. Bull Exp Biol Med 145, 104–107 (2008). https://doi.org/10.1007/s10517-008-0033-6

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  • DOI: https://doi.org/10.1007/s10517-008-0033-6

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