Abstract
We studied the effect of thymodepressin on migration and adhesion of mouse hemopoietic CD34+ cells under normal conditions and under the effect of granulocytic CSF. It was found that the peptide reduced the absolute number of CD34+ hemopoietic cells in the peripheral blood, increased the percent of cells bound to fibronectin and expressing receptor for integrin β1 (CD29+) in the bone marrow of mice under normal conditions and after stimulation with granulocytic CSF, and reduced the relative number of cells carrying CXCR4 receptor for stromal factor-1 (CD184+) in the bone marrow (CD34+CD184+) and blood (CD184+) of mice stimulated with granulocytic CSF. The results suggest that thymodepressin can inhibit migration of CD34+ cells from bone marrow into peripheral blood under conditions of normal and granulocytic CSF-stimulated hemopoiesis.
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References
O. V. Semina, T. N. Semenets, I. A. Zamulaeva, et al., Byull. Eksp. Biol. Med., 140, No. 9, 335–338 (2005).
V. I. Deigin, A. M. Poverenny, O. V. Semina, and T. N. Semenets, Immunol Lett., 6, No. 1, 41–46 (1999).
C. M. Verfaillie, R. Hurley, R. Bhatia, and J. B. McCarthy, Crit. Rev. Oncol. Hematol., 16, No. 3, 201–224 (1994).
F. Prosper, D. Stroncek, J. B. McCarthy, and C. M. Verfaillie, J. Clin. Invest., 101, No. 11, 2456–2467 (1998).
A. D. Whetton and G. J. Graham, Trends Cell Biol., 9, No. 6, 223–238 (1999).
Y. Sudo, C. Shimazaki, E. Ashihara, et al., Blood, 89, No. 9, 3186–3191 (1997).
A. C. Solimene, C. R. Carneiro, I. Melati, and J. D. Lopes, Braz. J. Med. Biol. Res., 3, No. 5, 653–661 (2001).
L. B. To, D. N. Haylock, P. J. Simmons, and C. A. Juttner, Blood, 89, No. 7, 2233–2238 (1997).
D. E. Wrigth, E. P. Bowman, F. J. Wagers, et al., J. Exp. Med., 195, No. 9, 1145–1151 (2002).
A. Peled, I. Petit, O. Kollet, et al., Science, 283, 845–848 (1999).
R. Bhatia, A. D. Williams, and H. A. Munthe, Exp. Hematol., 30, No. 4, 324–332 (2002).
M. Kucia, R. Reca, K. Miekus, et al., Stem Cells, 23, No. 7, 879–894 (2005).
K. M. Wiers, D. M. Lathers, M. A. Wright, and M. R. Young, J. Immunol., 23, No. 1, 115–124 (2000).
M. R. Young, G. J. Petruzzelli, K. Kolesiak, et al., Hum. Immunol., 62, No. 4, 332–341 (2001).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 12, pp. 682–685, December, 2007
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Semina, O.V., Semenets, T.N., Zamulaeva, I.A. et al. Thymodepressin inhibits migration of CD34+ cells from bone marrow in normal and granulocyte CSF-stimulated hemopoiesis. Bull Exp Biol Med 144, 831–834 (2007). https://doi.org/10.1007/s10517-007-0442-y
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DOI: https://doi.org/10.1007/s10517-007-0442-y