Abstract
Experiments on hepatocyte culture showed that apolipoprotein A-I—tetrahydrocortisol complex increases the rate of DNA, RNA, and protein biosynthesis measured by radioactive label incorporation. Apolipoprotein E acted as competitor of the apolipoprotein A-I—tetrahydrocortisol complex and abolished biological activity of the latter. We hypothesize that this mechanism of regulation plays an important role in processes of intracellular regeneration and proliferation.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 12, pp. 629–631, December, 2007
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Panin, L.E., Sumenkova, D.V., Knyazev, R.A. et al. Interaction of apolipoproteins A-I and E in the regulation of DNA, RNA, and protein biosynthesis in cultured rat hepatocytes. Bull Exp Biol Med 144, 780–782 (2007). https://doi.org/10.1007/s10517-007-0430-2
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DOI: https://doi.org/10.1007/s10517-007-0430-2