Abstract
Three months after myocardial infarction the severity of heart failure and size of postinfarction scars in August rats with inherently reduced adrenoreactivity of the myocardium were similar to those in Wistar rats. The mortality rate in August rats was 2.5-fold lower than in Wistar rats. During the postinfarction period, myocardial adrenoreactivity in August rats remained lower, while the efficiency of cardiac function was 62% higher than in Wistar rats. The incidence of epinephrine-induced arrhythmias in August rats was much lower than in Wistar rats.
Similar content being viewed by others
References
L. M. Belkina, T. N. Kirillina, M. G. Pshennikova, and Yu. V. Arkhipenko, Byull. Eksp. Biol. Med., 133, No. 6, 625–628 (2002).
L. M. Belkina, E. V. Popkova, V. L. Lakomkin, et al., Ros. Fiziol. Zh., 92, No. 2, 221–231 (2006).
L. M. Belkina, V. A. Saltykova, and M. G. Pshennikova, Byull. Eksp. Biol. Med., 131, No. 6, 624–628 (2001).
T. N. Kirillina, M. A. Usacheva, and L. M. Belkina, Ibid., 142, No. 10, 376–381 (2006).
E. G. Larskii, V. P. Barkhatova, and E. G. Demina, Lab. Delo, No. 9, 519–522 (1985).
V. D. Mikoyan, L. N. Kubrina, E. B. Manukhina, et al., Byull. Eksp. Biol. Med., 121, No. 6, 634–637 (1996).
S. S. Pertsov, E. V. Koplik, W. Krauzer, et al., Ibid., 123, No. 6, 645–648 (1997).
A. S. Poskrebysheva, V. V. Grinevich, Yu. V. Smurova, et al., Uspekhi Fiziol. Nauk, 3, No. 3, 3–20 (2003).
M. G. Pshennikova, L. M. Belkina, L. Yu. Bakhtina, et al., Byull. Eksp. Biol. Med., 132, No. 8, 153–155 (2001).
M. Packer, J. Am. Coll. Cardiol., 20, 248–254 (1992).
E. Vanoli and P. J. Schwartz, Basic Res. Cardiol., 85, Suppl. 1, 305–321 (1990).
P. Schwartz, R. Diem, N. J. Dun, and U. Forstermann, Circ. Res., 77, No. 4, 841–848 (1995).
Author information
Authors and Affiliations
Corresponding author
Additional information
__________
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 12, pp. 624–628, December, 2007
Rights and permissions
About this article
Cite this article
Usacheva, M.A., Popkova, E.V., Smirnova, E.A. et al. Adaptation of the cardiovascular system to postinfarction cardiosclerosis in rats with congenital adrenoreactivity of the myocardium. Bull Exp Biol Med 144, 775–779 (2007). https://doi.org/10.1007/s10517-007-0429-8
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10517-007-0429-8