Abstract
Low-dose (250 mg daily) oral probucol produces a significant antioxidant effect in coronary patients: increases activity of glutathione peroxidase (enzyme utilizing lipoperoxides) and reduces the content of free-radical oxidation products in the blood. Probucol therapy for 7 days before and for 6 months after coronary angioplasty significantly reduces the severity of coronary artery stenosis.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
N. K. Zenkov, N. V. Kandalintseva, V. Z. Lankin, Phenol Bioantioxidants [in Russian], Novosibirsk (2003).
V. Z. Lankin, A. K. Tikhaze, and Yu. N. Belenkov, Kardiologiya, 40, No. 7, 48–61 (2000).
E. B. Men’shchikova, N. K. Zenkov, V. Z. Lankin, et al., Oxidative Stress. Biochemical and Pathophysiological Aspects [in Russian], Moscow (2001).
A. K. Tikhaze, V. Z. Lankin, E. A. Zharova, and S. V. Kolycheva, Byull. Eksp. Biol. Med., 126, No. 12, 98–99 (1998).
A. K. Tikhaze, V. Z. Lankin, and S. V. Kolycheva, Ibid., 130, No. 10, 395–398 (2000).
A. K. Tikhaze, V. Z. Lankin, G. G. Konovalova, K. B. Shumaev, et al., Ibid., 128, No. 8 186–189 (1999).
A. C. Newby, Toxicol. Lett., 112–113, 519–529 (2000).
J. Nourooz-Zadeh, J. Tajaddini-Sarmadi, and S. P. Wolff, Anal. Biochem., 220, No. 2, 403–409 (1994).
M. A. Rossi, M. Curzio, C. Di Mauro, et al., Cell. Biochem. Funct., 9, No. 3, 163–170 (1991).
J. C. Tardif, G. Cöte, J. Lespérance, et al., N. Engl. J. Med., 337, No. 6, 365–372 (1997).
J. C. Tardif, J. Grégoire, L. Schwartz, et al., Circulation, 107, No. 4, 552–558 (2003).
V. V. Tertov, V. V. Kaplun, S. N. Dvoryantsev, and A. N. Orekhov, Biochem. Biophys. Res. Commun., 214, No. 2, 608–613 (1995).
T. Wakeyama, H. Ogawa, H. Iida, et al., Circ. J., 67, No. 6, 519–524 (2003).
H. Yakoi, H. Daida, Y. Kuwabara, et al., J. Am. Coll. Cardiol., 30, No. 4, 855–862 (1997).
Author information
Authors and Affiliations
Corresponding author
Additional information
__________
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 11, pp. 503–506, November, 2007
Rights and permissions
About this article
Cite this article
Kaminnyi, A.I., Lankin, V.Z., Perepelitsa, E.I. et al. Relationship between free-radical lipid oxidation and efficiency of coronary angioplasty in coronary patients. Bull Exp Biol Med 144, 664–666 (2007). https://doi.org/10.1007/s10517-007-0399-x
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10517-007-0399-x