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Polyunsaturated Fatty Acids and Their Correlations with Parameters of Oxidative/Antioxidant Potential of the Blood and Lipoprotein-Associated Phospholipase A2 in Coronary Atherosclerosis

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We studied serum content of some polyunsaturated fatty acids and their correlations with parameters of oxidative stress (FORT), antioxidant protection (FORD), lipoprotein-associated phospholipase A2 (LP-PLA2), and serum level of LPO products in male patients with coronary atherosclerosis. The mass fraction of polyunsaturated fatty acids and FORD were lower, while LP-PLA2, FORT, and concentration of LPO products were higher than in the control group (conventionally healthy men). Negative correlations of medium strength of polyunsaturated fatty acids with inflammation markers and oxidative stress were revealed, which can indicate that the decrease in polyunsaturated fatty acids content is associated with enhanced generation of free radicals, and consequently with increased risk of early atherosclerosis development.

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Authors and Affiliations

  1. Research Institute of Internal and Preventive Medicine, Affiliated Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    V. S. Shramko, YA. V. Polonskaya & Yu. I. Ragino

  2. N. N. Vorozhtsov Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    S. V. Morozov & E. I. Chernyak

  3. E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation, Novosibirsk, Russia

    A. M. Chernyavsky

Authors
  1. V. S. Shramko
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  2. YA. V. Polonskaya
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  3. S. V. Morozov
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  4. E. I. Chernyak
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  5. A. M. Chernyavsky
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  6. Yu. I. Ragino
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Corresponding author

Correspondence to V. S. Shramko.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 7, pp. 14-17, July, 2018

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Shramko, V.S., Polonskaya, Y.V., Morozov, S.V. et al. Polyunsaturated Fatty Acids and Their Correlations with Parameters of Oxidative/Antioxidant Potential of the Blood and Lipoprotein-Associated Phospholipase A2 in Coronary Atherosclerosis. Bull Exp Biol Med 166, 11–14 (2018). https://doi.org/10.1007/s10517-018-4277-5

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  • DOI: https://doi.org/10.1007/s10517-018-4277-5

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