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Effect of inhibitors of arachidonic acid conversion in platelets on thrombin—fibrinogen interaction and thrombin tolerance

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Abstract

Experiments on 200 rats showed that inhibitors of arachidonic acid conversion capable of reducing coagulation activity of platelets decrease the content of markers for thrombin—fibrinogen interaction in the plasma and, therefore, decelerate intravascular blood coagulation and increase thrombin tolerance.

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Authors and Affiliations

  1. Department of Biochemistry, Tyumen Medical Academy, Russian Ministry of Health, Russia

    E. M. Shapovalova & A. J. Rudzevich

Authors
  1. E. M. Shapovalova
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  2. A. J. Rudzevich
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Correspondence to E. M. Shapovalova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 10, pp. 408–409, October, 2007

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Shapovalova, E.M., Rudzevich, A.J. Effect of inhibitors of arachidonic acid conversion in platelets on thrombin—fibrinogen interaction and thrombin tolerance. Bull Exp Biol Med 144, 527–528 (2007). https://doi.org/10.1007/s10517-007-0368-4

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  • DOI: https://doi.org/10.1007/s10517-007-0368-4

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