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Effect of a New Antioxidant Enoxifol on Platelet Aggregation and Blood Rheological Properties in Rats with Experimental Diabetes Mellitus

  • PHARMACOLOGY AND TOXICOLOGY
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Effect of a new antioxidant enoxifol exhibiting antiplatelet activity in vitro and in vivo on hemostasis parameters was assessed in laboratory rats with experimental diabetes mellitus. Gliclazide, a hypoglycemic agent with antiplatelet properties, and pentoxifylline, a preparation improving blood rheology, were used as the reference drugs. Enoxifol produced a pronounced inhibitory effect on platelet aggregation in rats with experimental diabetes comparable to the effect of gliclazide and decreased blood viscosity thus demonstrating a significant effect comparable to that of pentoxifylline. In view of the fact that oxidative stress is a pathogenetic components of vascular complications in diabetes, it can be assumed that improvement of hemostasis parameters under the effect of enoxifol is determined by its antiplatelet and antioxidant activities.

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Authors and Affiliations

  1. Department of Pharmacology, Volgograd State Medical University, Volgograd, Russia

    A. F. Kucheryavenko & A. A. Spasov

  2. Research Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia

    V. A. Anisimova

Authors
  1. A. F. Kucheryavenko
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  2. A. A. Spasov
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  3. V. A. Anisimova
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Corresponding author

Correspondence to A. F. Kucheryavenko.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 12, pp. 721-724, December, 2015

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Kucheryavenko, A.F., Spasov, A.A. & Anisimova, V.A. Effect of a New Antioxidant Enoxifol on Platelet Aggregation and Blood Rheological Properties in Rats with Experimental Diabetes Mellitus. Bull Exp Biol Med 160, 759–762 (2016). https://doi.org/10.1007/s10517-016-3303-8

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  • DOI: https://doi.org/10.1007/s10517-016-3303-8

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