Abstract
We formulated a new approach to the creation of transport proteins for the delivery of foreign DNA to target cells and used it for obtaining a polypeptide PGEk. Structural and functional analysis of PGEk—DNA complexes demonstrated good prospects for the creation of a wide spectrum of targeted preparations for gene therapy. These approaches and regularities are necessary for construction of new DNA carriers selective for various cell types.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Supplement 2, pp. 87–93, April, 2007
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Pozmogova, G.E., Chuvilin, A.N. Principles of creation of protein carriers of DNA new derivatives of human epidermal growth factor for gene therapy. Bull Exp Biol Med 144, 457–463 (2007). https://doi.org/10.1007/s10517-007-0351-0
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DOI: https://doi.org/10.1007/s10517-007-0351-0