Abstract
Contractile activity of atrial and ventricular myocardial strips isolated from rats of various age was examined under conditions of blockade of non-selective hyperpolarization-activated cation currents. Addition of ZD7288, a blocker of non-selective hyperpolarization-activated cation currents, to the perfusion solution increased the contraction force of atrial and ventricular strips in 1-, 8-, and 20-week rats, but produced an opposite effect on contractile activity of atrial and ventricular strips in 3-week rats.
Similar content being viewed by others
References
T. L. Zefirov, N. I. Ziyatdinova, A. A. Gainullin, and A. L. Zefirov, Byull. Eksp. Biol. Med., 133, No. 5, 492–495 (2002).
T. L. Zefirov, N. I. Ziyatdinova, A. A. Gainullin, and A. L. Zefirov, Neirofiziol., 35, No. 6, 455–462 (2003).
T. L. Zefirov, N. V. Svyatova, and N. I. Ziyatdinova, Byull. Eksp. Biol. Med., 131, No. 6, 612–616 (2001).
N. I. Ziyatdinova, R. A. Giniatullin, N. V. Svyatova, and T. L. Zefirov, Ibid., No. 3, 256–259.
N. I. Ziyatdinova and T. L. Zefirov, Ibid., 133, No 1, 11–13 (2002).
N. I. Ziyatdinova, A. L. Zefirov, F. G. Sitdikov, and T. L. Zefirov, Ross. Fiziol. Zh., 89, No. 2, 154–160 (2003).
A. Bucchi, A. Tognati, R. Milanesi, et al., J. Physiol., 572, Pt. 2, 335–346 (2006).
E. Cerbai and A. Mugelli, Pharmacol. Res., 53, No. 5, 416–423 (2006).
I. S. Cohen and R. B. Robinson, Handb. Exp. Pharmacol., 171, 41–71 (2006).
D. DiFrancesco, Curr. Med. Res. Opin., 21, No. 7, 1115–1122 (2005).
D. DiFrancesco, Prog. Biophys. Mol. Biol., 90, No. 1–3, 13–25 (2006).
D. DiFrancesco, Pharmacol. Res., 53, No. 5, 399–406 (2006).
R. C. Hogg, A. A. Harper, and D. J. Adams, J. Neurophysiol., 86, No. 1, 312–320 (2001).
R. Milanesi, M. Baruscotti, T. Gnecchi-Ruscone, and D. Di-Francesco, N. Engl. J. Med., 354, No. 2, 151–157 (2006).
R. B. Robinson, P. R. Brink, I. S. Cohen, and M. R. Rosen, Pharmacol. Res., 53, No. 5, 407–415 (2006).
Author information
Authors and Affiliations
Corresponding author
Additional information
__________
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 9, pp. 244–246, September, 2007
Rights and permissions
About this article
Cite this article
Zefirov, T.L., Gibina, A.E., Sergejeva, A.M. et al. Age-related peculiarities of contractile activity of rat myocardium during blockade of hyperpolarization-activated currents. Bull Exp Biol Med 144, 273–275 (2007). https://doi.org/10.1007/s10517-007-0308-3
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10517-007-0308-3