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Effects of α1-acid glycoprotein on free radical oxidation processes in experimental liver failure

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Abstract

The effects of α1-acid glycoprotein (2 intraperitoneal injections in a total dose of 300 mg/kg) on free radical oxidation during liver failure were studied in 53 outbred rats. On day 3 of liver failure, glycoprotein reduced plasma concentrations of free radical oxidation products, elevated the antioxidant potential of the plasma and liver and kidney homogenates, and restored functional reserve and capacity of leukocytes to generation of oxygen radicals.

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References

  1. P. G. Nazarov, Acute Phase Inflammation Reactants [in Russian], St. Petersburg (2001).

  2. M. V. Osikov and L. V. Krivokhizhina, Efferent. Ter., No. 2, 43–46 (2006).

  3. M. V. Osikov, L. V. Krivokhizhina, and A. V. Mal’tsev, Ibid., No. 4, 36–39.

  4. A. L. Pukhal’skii, G. V. Shmarina, and A. G. Lyutov, Byull. Eksp. Biol., 131, No. 5, 564–567 (2001).

    Google Scholar 

  5. V. V. Salomatin, A. G. Lyutov, A. Yu. Kholodov, et al., Patol. Fiziol. Eksper. Ter., No. 1, 35–37 (1992).

  6. R. R. Farkhutdinov and V. A. Likhovskikh, Chemiluminescent Methods for Studies of Free Radical Oxidation in Biology and Medicine [in Russian], Ufa (1998).

  7. S. Chanda and H. M. Mehendale, FASEB J., 9, No. 2, 240–245 (1995).

    PubMed  CAS  Google Scholar 

  8. T. Kimura, N. Itoh, M. Takehara, et al., Biochem. Biophys. Res. Commun., 280, No. 1, 358–362 (2001).

    Article  PubMed  CAS  Google Scholar 

  9. H. Kuzuhara, Y. Nakano, N. Yamashita, et al., Eur. J. Pharm., 541, No. 3, 205–210 (2006).

    Article  CAS  Google Scholar 

  10. E. V. Makarov, M. V. Osikov, and L. V. Krivokhizhina, Int. J. Artif. Organs, 28, 931 (2005).

    Google Scholar 

  11. W. Van Molle, C. Libert, W. Fiers, and P. Brouckaert, J. Immunol., 159, No. 7, 3555–3564 (1997).

    PubMed  Google Scholar 

  12. J. Sorrenson, M. Ohlson, A. Bjornson, and B. Haraldsson, Am. J. Physiol. Heart Circ. Physiol., 278, No. 5, H1725–H1731 (2000).

    Google Scholar 

  13. N. Tygstrup, S. A. Jensen, B. Krog, and K. Dalhoff, J. Hepatol., 25, No. 2, 183–190 (1996).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pathophysiology, Chelyabinsk State Medical Academy, Russia

    M. V. Osikov

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  1. M. V. Osikov
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Correspondence to M. V. Osikov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 7, pp. 29–31, July, 2007

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Osikov, M.V. Effects of α1-acid glycoprotein on free radical oxidation processes in experimental liver failure. Bull Exp Biol Med 144, 26–28 (2007). https://doi.org/10.1007/s10517-007-0244-2

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  • DOI: https://doi.org/10.1007/s10517-007-0244-2

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