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Selective antitumor activity of lymphokine-activated killer cells in vitro

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

We compared cytotoxic activity of blood mononuclear leukocytes from healthy donors and lymphokine-activated killer cells generated from them towards tumor and normal cells. Lymphokine-activated killer cells exhibited higher (in comparison with blood mononuclear leukocytes) killer activity towards tumor cells. Lymphokine-activated cells and mononuclear leukocytes had no lytic effect on non-transformed eukaryotic cells. Hence, we demonstrated selective cytotoxic activity of effector cells (lymphokine-activated killers) towards tumor cells of different origin (but not normal cells).

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References

  1. M. V. Kiselevskii, Vestn. Rossiisk. Akad. Med. Nauk, No. 3, 40–44 (2003).

  2. N. V. Berezhnaya, U. D. Vinnichuk, V. F. Konovalenko, et al., Exp. Oncol., 27, 303–307 (2005).

    PubMed  CAS  Google Scholar 

  3. C. E. Hormanski, R. Truax, S. S. Pourciau, et al., Vet. Immunol. Immunopathol., 32, 25–36 (1992).

    Article  PubMed  CAS  Google Scholar 

  4. I. Noda, S. Fujieda, H. Saito, et al., Anticancer Res., 14, 1117–1120 (1994).

    PubMed  CAS  Google Scholar 

  5. S. A. Rosenberg, B. Lotze, J. C. Yang, et al., J. Natl. Cancer Inst., 85, 662–632 (1993).

    Article  Google Scholar 

  6. N. N. Sotiriadou, S. A. Perez, A. D. Gritzapis, et al., Cell. Immunol., 234, 67–75 (2005).

    Article  PubMed  CAS  Google Scholar 

  7. Y. J. Zheng, J. Zhang, S. M. Wang, and J. B. Zvang, Di Yi Jun Yi Da Xue Xue Bao, 24, 392–396 (2004).

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Cell-Mediated Immunity, N. N. Blokhin National Cancer Research Center, Russian Academy of Medical Sciences, Moscow

    O. S. Zhukova, I. Zh. Shubina, G. K. Gerasimova, A. M. Karamzin & M. V. Kiselevskii

  2. Department of Histology, Perm State Medical Academy, Ministry of Health of the Russian Federation, Russia

    O. V. Lebedinskaya

Authors
  1. O. S. Zhukova
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  2. O. V. Lebedinskaya
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  3. I. Zh. Shubina
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  4. G. K. Gerasimova
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  5. A. M. Karamzin
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  6. M. V. Kiselevskii
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Corresponding author

Correspondence to O. V. Lebedinskaya.

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Translated from Kletochnye Tehnologii v Biologii i Medicine, No. 1, pp. 21–25, January, 2007

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Zhukova, O.S., Lebedinskaya, O.V., Shubina, I.Z. et al. Selective antitumor activity of lymphokine-activated killer cells in vitro . Bull Exp Biol Med 143, 132–135 (2007). https://doi.org/10.1007/s10517-007-0033-y

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  • DOI: https://doi.org/10.1007/s10517-007-0033-y

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