Abstract
We studied the state of the bone marrow Thy-1,2+ cell pool under conditions of severe hypoxia. T cell mechanisms of hemopoiesis regulation are preserved under conditions of severe oxygen deficiency due to changes in functional properties of Thy-1,2+ cells. We revealed an indirect (mediated through cooperation with adherent myelokaryocytes) stimulating effect of Thy-1,2+ cells on erythroid precursors as well as direct and indirect feeder effects of these cells on granulocyte-monocyte precursors.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 1, pp. 23–27, January, 2007
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Gol’dberg, E.D., Dygai, A.M. & Zyuz’kov, G.N. Role of Thy-1,2+ cells in the regulation of hemopoiesis during severe hypoxia. Bull Exp Biol Med 143, 18–21 (2007). https://doi.org/10.1007/s10517-007-0006-1
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DOI: https://doi.org/10.1007/s10517-007-0006-1