Abstract
The effect of 5-methoxytryptamine (5-HT4 receptor agonist) on the inotropic function of atrial myocardium was studied in children aged 2 months to 17 years, operated on for congenital heart disease. Functional activity of 5-HT4 receptors was 8.4 times higher in dysfunction of the atrial septum in comparison with other congenital heart diseases. The positive inotropic effects of 5-HT4 receptor agonist can promote compensation of myocardial work in children with pathological circulation.
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References
V. F. Akhmetzyanov, R. R. Nigmatullina, A. F. Akhmetzyanova, and I. A. Latfullin, Arkh. Klin. Eksp. Med., 13, Nos. 1–2, 2–25 (2004).
R. R. Nigmatullina, V. F. Akhmetzyanov, D. I. Nasyrova, and A. F. Akhmetzyanova, Morfol. Vedomosti, Nos. 1–2, 72–73 (2004).
W. H. Frishman and P. Grewall, Ann. Med., 32, No. 3, 195–209 (2000).
B. I. Gustafsson, K. Tommeras, I. Nordrum, et al., Circulation, 111, No. 12, 1517–1522 (2005).
P. Herve, J. M. Launay, M. L. Scrobohaci, et al., Am. J. Med., 99, No. 3, 249–254 (1995).
A. J. Kaumann, Trends Pharmacol. Sci., 15, No. 12, 451–455 (1994).
A. Kereveur, J. Callebert, M. Humbert, et al., Arterioscler. Thromb. Vasc. Biol., 20, No. 10, 2233–2240 (2000).
C. G. Nebigil, D. S. Choi, A. Dierich, et al., Proc. Natl. Acad. Sci. USA, 97, No. 17, 9508–9513 (2000).
C. G. Nebigil, D. Pharm, and L. Maroteaux, Circulation, 108, No. 7, 902–908 (2003).
R. Pino, E. Cerbai, G. Calamai, et al., Cardiovasc. Res., 40, No. 3, 516–522 (1998).
D. W. Richter, T. Manzke, B. Wilken, and E. Ponimaskin, Trends Mol. Med., 9, No. 12, 542–548 (2003).
C. Tournois, V. Mutel, and P. Manivet, J. Biol. Chem., 273, No. 28, 17,498–17,503 (1998).
M. V. Ugrumov, A. P. Popov, S. V. Vladimirov, et al., Neuroscience, 58, No. 1, 161–165 (1994).
K. Vikenes, M. Farstad, and J. E. Nordrehaug, Circulation, 100, No. 5, 483–489 (1999).
S. Yusuf, N. Al-Saadi, and A. J. Camm, J. Cardiovasc. Electrophysiol., 14, No. 2, 209–214 (2003).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 12, pp. 675–677, December, 2006
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Mustafin, A.A., Nigmatullina, R.R. & Mirolyubov, L.M. Functional activity of 5-HT4 receptors in children with congenital heart disease. Bull Exp Biol Med 142, 717–719 (2006). https://doi.org/10.1007/s10517-006-0460-1
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DOI: https://doi.org/10.1007/s10517-006-0460-1