Abstract
Antinociceptive activity of dalargin (7.5 mg/kg) adsorbed on poly(butyl)cyanoacrylate nanoparticles with different coating was studied on outbred albino mice by the tail-flick test. Poly(butyl)cyanoacrylate nanoparticles without coating did not increase the antinociceptive activity of dalargin and hence, did not increase its transport across the blood-brain barrier. Poly(butyl)cyanoacrylate nanoparticles coated with apolipoprotein B, apolipoprotein E, and polysorbate 80 increased the transport of dalargin across the blood-brain barrier. Delivery of dalargin to the brain was most effective in case of using poly(butyl)cyanoacrylate nanoparticles with polysorbate 80 coating and subsequent supercoating with apolipoprotein E.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 12, pp. 659–662, December, 2006
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Shamenkov, D.A., Petrov, V.E. & Alyautdin, R.N. Effects of apolipoproteins on dalargin transport across the blood-brain barrier. Bull Exp Biol Med 142, 703–706 (2006). https://doi.org/10.1007/s10517-006-0456-x
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DOI: https://doi.org/10.1007/s10517-006-0456-x