Abstract
A decrease in carboplatinum hemotoxicity was detected in experiments on C57Bl mice treated with the drug in combination with indralin (urgent radioprotector). Carboplatinum in a dose of 125 mg/kg, injected intraperitoneally, caused 80–100% death; the median term of death was 6 days (3–17). Single oral dose of indralin (100 mg/kg) during the 1st min or 15 min after carboplatinum injection (125 mg/kg) increased animal survival by 40.0–46.7% by day 20 of the experiment primarily during the period of manifest hemotoxicity (days 7–17), indralin injected 1, 2, or 4 h after carboplatinum exhibited no chemoprotective effect.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
M. V. Vasin, I. B. Ushakov, L. A. Semenova, and V. Yu. Kovtun, Radiats. Biol. Radioekol., 41, No. 3, 307–309 (2001).
L. A. Il’in, N. M. Rudnyi, N. N. Suvorov, et al., Indralin: Urgent Radioprotector. Antiradiation Effects, Pharmacology, Mechanism of Action, Clinical Picture [in Russian], Moscow (1994).
M. K. Pulatova, V. L. Sharygin, and T. G. Shlyakova, Radiats. Biol. Radioekol., 43, No. 1, 29–43 (2003).
G. A. Chernov, T. G. Shlyakova, V. L. Sharygin, et al., Izv. Akad. Nauk, ser. Biology, No. 1, 20–37 (1994).
C. S. Broome and J. A. Miyan, Ann. NY Acad. Sci., 917, 424–434 (2000).
G. J. Maestroni, Pharmacol. Res., 32, No. 5, 249–253 (1995).
G. J. Maestroni, Ann. N.Y. Acad. Sci., 917, 29–37 (2000).
G. J. Maestroni and A. Conti, Exp. Hematol., 22, No. 3, 313–320 (1994).
G. J. Maestroni and A. Conti, Int. J. Immunopharmacol., 16, No. 2, 117–122 (1994).
G. J. Maestroni, A. Conti, and E. Pedrinis, Blood, 80, 1178–1182 (1992).
G. J. Maestroni, M. Togni, and V. Covacci, Exp. Hematol., 25, No. 6, 491–494 (1997).
V. Santini, Exp. Opin. Pharmacother., 2, No. 3, 479–489 (2001).
C. Savoye, C. Swenberg, S. Hugot, et al., Int. J. Radiat. Biol., 71, No. 2, 193–202 (1997).
Author information
Authors and Affiliations
Additional information
__________
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 4, pp. 422–424, April, 2006
Rights and permissions
About this article
Cite this article
Vasin, M.V., Ushakov, I.B., Kovtun, V.Y. et al. Effect of radioprotector indralin on carboplatinum hemotoxicity. Bull Exp Biol Med 141, 437–439 (2006). https://doi.org/10.1007/s10517-006-0193-1
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10517-006-0193-1