Abstract
We studied the effects of optical (dd-, ll-, dl-, and ld-dipeptides with α-bond, EW) structural isomers and cyclic (dd-, ll-, dl-, and ld-dipeptides with γ-bond, iEW) analogs of Glu-Trp synthetic dipeptide on the population of normal hemopoietic stem cells. Dipeptides containing lGlu (lGlu-lTrp, lGlu-dTrp) injected to mice were inert towards committed bone marrow CFU-S; dGlu-containing dipeptides (dGlu-dTrp, dGlu-lTrp) inhibited the growth of CFU-S-8; and LiGlu-dTrp stimulated these cells. Inhibitory or stimulatory effects of optical and chemical isomers of Glu-Trp dipeptide are determined by optical orientation and nature of peptide bond of Glu residue. The effects of cyclic and mixed peptides towards colony formation are similar to those of the corresponding linear dipeptides.
Similar content being viewed by others
References
Yu. E. Vinogradova, V. I. Deigin, O. V. Semina, et al., Ros. Onkol. Zh., No. 2, 45–48 (1999).
A. M. Poverennyi, O. V. Semina, T. N. Semenets, et al., Immunologiya, No. 2, 102–104 (2002).
V. I. Deigin, A. M. Poverennyi, O. V. Semina, and T. N. Semenets, Immunol. Lett., 67, 41–46 (1999).
C. Li, I. McCarty, L. Furcht, et al., Biochemistry, 34, 49–59 (1997).
J. E. Till and E. A. McCulloch, Radiat. Res., 14, 213–222 (1961).
Author information
Authors and Affiliations
Additional information
__________
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 2, pp. 214–216, February, 2006
Rights and permissions
About this article
Cite this article
Semina, O.V., Semenets, T.N., Zamulaeva, I.A. et al. Effects of structural and “mixed” isomers of Glu-Trp dipeptide on normal hemopoietic stem cells. Bull Exp Biol Med 141, 250–253 (2006). https://doi.org/10.1007/s10517-006-0141-0
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10517-006-0141-0