Abstract
We studied the effects of α1-acid glycoprotein preparations on the survival rate of BALB/c mice infected with the lethal dose of B. anthracis STI-1. Apart from native α1-acid glycoprotein from donor blood, we studied 3 glycoforms differing in the affinity for concanavalin A and structure of carbohydrate chains. The protective effect of α1-acid glycoprotein preparations did not depend on its dose and was observed 3 months after treatment (0.3 mg per mouse). The protective effect was revealed in mice receiving α1-acid glycoprotein preparations 2 h before infection and 24 h after inoculation of the bacterial culture. In the latter case the survival rate of animals was much higher compared to that observed in preventive administration of α1-acid glycoprotein. The protective effect practically did not depend on the time of treatment with glycoforms. Pretreatment with α1-acid glycoprotein preparations significantly decreased plasma interferon-γ concentration. Administration of the test preparations 24 h after infection decreased the concentration of tumor necrosis factor-α.
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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 140, No. 10, pp. 440–445, October, 2005
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Shemyakin, I.G., Pukhalsky, A.L., Stepanshina, V.N. et al. Preventive and Therapeutic Effects of α1-Acid Glycoprotein in Mice Infected with B. anthracis . Bull Exp Biol Med 140, 439–444 (2005). https://doi.org/10.1007/s10517-005-0514-9
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DOI: https://doi.org/10.1007/s10517-005-0514-9