Abstract
Differentiation of human embryonic retinal cells (20–22 weeks’ gestation) was studied using morphological, immunohistochemical, and biomolecular approaches. The retina included several regions differing by the degree of cell differentiation. Mitoses were rarely found in the marginal zone. This zone contained low differentiated cells. The central retinal area consisted of typical layers with differentiated cells. Culturing was accompanied by the formation of aggregates and neurospheres, where mitoses and progenitor or differentiated cells expressing markers of photoreceptors, neurons, and glia were found.
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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 2, pp. 103–109, 2005
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Panova, I.G., Podgornyi, O.V., Verdiev, B. et al. In Vivo and in Vitro Proliferative and Differentiation Activity of Human Embryonic Retinal Cells. Bull Exp Biol Med 139, 517–522 (2005). https://doi.org/10.1007/s10517-005-0334-y
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DOI: https://doi.org/10.1007/s10517-005-0334-y