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Effect of dehydroepiandrosterone on radioligand binding of [3H]-testosterone by androgen receptors in rat hypothalamus

  • Pharmacology and Toxicology
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Abstract

Intramuscular injections of dehydroepiandrosterone in a dose of 0.7 mg/kg for 10 days significantly increased nuclear and cytoplasmic fractions of androgen receptors in the preoptic/anterior hypothalamic area. Presumably, the effect of the neurosteroid is mediated by 5α-reductase transformation of dehydroepiandrosterone into 5α-dehydroepiandrosterone, which initiates the synthesis of androgen receptors.

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Authors and Affiliations

  1. Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg

    A. A. Bairamov & N. S. Sapronov

Authors
  1. A. A. Bairamov
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  2. N. S. Sapronov
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 10, pp. 435–438, October, 2004

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Bairamov, A.A., Sapronov, N.S. Effect of dehydroepiandrosterone on radioligand binding of [3H]-testosterone by androgen receptors in rat hypothalamus. Bull Exp Biol Med 138, 387–389 (2004). https://doi.org/10.1007/s10517-005-0107-7

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  • DOI: https://doi.org/10.1007/s10517-005-0107-7

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