A scheme for producing the α-emitters 212Pb and 212Bi, to be used in a promising method of diagnostics and therapy in oncology – radioimmunotherapy, is proposed. The technology is based on two generators operating in tandem: 228Th/212Pb and 212Pb/212Bi. The first one is based on separation from an initial solution containing thorium isotopes and gaseous 220Rn, which secures the purity of the desired products 212Pb and 212Bi. For a 228Th/212Pb model generator, the efficiency of 220Rn extraction from solution was ~60%. After conditioning, the 212Pb solution from the 228Th/212Pb generator was used to charge a column, which functioned as a 212Pb/212Bi generator, with a cation exchanger.
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Translated from Atomnaya Énergiya,Vol. 111, No. 6, pp. 348–352, December, 2011.
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Boldyrev, P.P., Bortash, A.I., Zagryadskii, V.A. et al. 212Pb/212Bi Generator for nuclear medicine. At Energy 111, 422–427 (2012). https://doi.org/10.1007/s10512-012-9513-x
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DOI: https://doi.org/10.1007/s10512-012-9513-x