Abstract
Apoptosis repressor with caspase recruitment domain (ARC) acts as a potent and multifunctional inhibitor of apoptosis, which is mainly expressed in postmitotic cells, including cardiomyocytes. ARC is special for its N-terminal caspase recruitment domain and caspase recruitment domain. Due to the powerful inhibition of apoptosis, ARC is mainly reported to act as a cardioprotective factor during ischaemia‒reperfusion (I/R) injury, preventing cardiomyocytes from being devastated by various catastrophes, including oxidative stress, calcium overload, and mitochondrial dysfunction in the circulatory system. However, recent studies have found that ARC also plays a potential regulatory role in tumorigenesis especially in colorectal cancer and renal cell carcinomas, through multiple apoptosis-associated pathways, which remains to be explored in further studies. Therefore, ARC regulates the body and maintains the balance of physiological activities with its interesting duplex. This review summarizes the current research progress of ARC in the field of tumorigenesis and ischaemia/reperfusion injury, to provide overall research status and new possibilities for researchers.
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The data that support the fndings of this study are available from the corresponding author upon reasonable request.
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Acknowledgements
This work was supported by the National Nature Science Foundation of China (NSFC. 31960156, 31660338, 32270848); Collaborative Innovation Center of Chinese Ministry of Education (2020-39); Science and Technology Support Program of Guizhou Province (QKH[2020]4Y192); Science and Technology Program of Guizhou Province (QKH[2019]5406, QKH-[2021]111); Science and Technology Fund of Guizhou Provincial Health Commission (gzwkj2022-019).
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All authors contributed to the study conception and design. Kun Liu was responsible for article design and manuscript writing. Dongfeng Lan was involved in the design of the images. Zhixu He, Jidong Zhang and Jun Tan was involved in the design of the study, revise the manuscript, and funding application. All authors read and approved the final manuscript. All authors declared no competing interests. The first draft of the manuscript was written by Kun Liu and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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Liu, K., Lan, D., Li, C. et al. A double-edged sword: role of apoptosis repressor with caspase recruitment domain (ARC) in tumorigenesis and ischaemia/reperfusion (I/R) injury. Apoptosis 28, 313–325 (2023). https://doi.org/10.1007/s10495-022-01802-4
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DOI: https://doi.org/10.1007/s10495-022-01802-4