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Apoptosis

, Volume 12, Issue 5, pp 951–968 | Cite as

IP3 receptors in cell survival and apoptosis: Ca2+ release and beyond

  • Suresh K. Joseph
  • György Hajnóczky
Article

Abstract

Inositol 1,4,5-trisphosphate receptors (IP3Rs) serve to discharge Ca2+ from ER stores in response to agonist stimulation. The present review summarizes the role of these receptors in models of Ca2+-dependent apoptosis. In particular we focus on the regulation of IP3Rs by caspase-3 cleavage, cytochrome c, anti-apoptotic proteins and Akt kinase. We also address the evidence that some of the effects of IP3Rs in apoptosis may be independent of their ion-channel function. The role of IP3Rs in delivering Ca2+ to the mitochondria is discussed from the perspective of the factors determining inter-organellar dynamics and the spatial proximity of mitochondria and ER membranes.

Keywords

Apoptosis Calcium Endoplasmic reticulum IP3 IP3 receptor Mitochondria 

Abbreviations

NFAT

Nuclear factor of activated T-cells

ER

endoplasmic reticulum

MEF

murine embryo fibroblasts

HIV

Human immunodeficiency virus

STS

staurosporine

Bcl-2

B cell lymphoma 2

Bcl-xL

B cell lymphoma xL

IP3R

Inositol 1,4,5-trisphosphate receptors

RyR

Ryanodine receptor

FasL

Ligand for Fas receptor (CD95)

VDAC

Voltage dependent anion selective channel

[Ca2+]c

cytoplasmic free [Ca2+]

[Ca2+]m

mitochondrial matrix free [Ca2+]

OMM

outer mitochondrial membrane

IMM

inner mitochondrial membrane

PTP

permeability transition pore

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Copyright information

© Springer Science + Business Media, LLC 2007

Authors and Affiliations

  1. 1.Department of Pathology & Cell BiologyThomas Jefferson UniversityPhiladelphiaUSA

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